Is there a relationship between metformin-related gastrointestinal symptoms and vitamin B12 deficiency in patients with type 2 diabetes mellitus?

Metformin (MTF) associated gastrointestinal symptoms are fairly common side effects that adversely affect patients' treatment adherence. However, the variability of in MTF-using patients has not been fully explained. In our study, we aimed to investigate relationship between vitamin B12 deficiency with MTF-related symptoms. Patients type 2 diabetes mellitus (T2DM) using MTF were included study sequentially. Demographic characteristics patients, duration diabetes, dose and used, recorded. Afterward, a hemogram, HgbA1c, measurements performed. without divided into two groups. The groups compared statistical methods. Twenty-five percent had low serum levels. longer duration, usage (p<0.001, p<0.001) than deficiency. There was no correlation dosage (p=0.590). Gastrointestinal seen more frequently group (p=0.025). Bloating constipation, nausea, abdominal pain, vomiting commonly (p=0.002, p<0.001, p=0.014, p=0.004, respectively). Three or B12-deficient (p<0.001). both 10 years higher found be 434% likely have active all other patient (OR:5.343, 95%CI (2.173-13.140), p<0.001). Study results shown T2DM taking may gut microbiome changes play role this relationship. particular, recommend who for ≥10 complaints should followed closely